Innate Immunity R&D

Children's Amazing Immunity

Our Early Pandemic Treatment and Cure R&D

01

Viral Attachment via Endosomes

The Innate Immune system - the master brain of human pathogen and trauma response - was known for years to be the real determinant of human survival against corona; and when Covid19 struck, Innate Immunity was also found to be the single determinant of how quickly, and whether, a victim would recover from the virus.

For the first two years of the pandemic, over 98% of all human adults and 100% of all human children worldwide, survived Covid19 without any vaccine, protected only by their natural Innate Immunity. Our early work focused entirely on mechanisms and variance for Innate Immunity worldwide; the delta(s) between child and adult Innate Immunity; and the deltas between asymptomatic adults and the fractional percent who became ill and/or died.

This led us to focus on Vitamin D, as a causative factor given its regulatory control role in Innate Immunity, and the persistent findings of Vitamin D depletion in Covid19 mortality victims worldwide.

Initially it was thought that the Innate Immune system only regulated endosomic infection by the virus; and that slower, back-end Adaptive Immunity - which the vaccines ought to emulate; in contrast to treatment and cure R&D seeking to emulate front-end Innate defense - was regulated by the Innate system. But that later proved incorrect; Innate Immunity ultimately governs every element of the Covid19 - human microbial architecture.

02

Viral Attachment via Plasma Membrane

Inhibiting the precursors or elements required for Cov19 to attach to ACE2 initially - lividomycin, burixafor, quisinostat, fluprofylline, pemetrexed, spirofylline, edotecarin, and diniprofylline (PMC7377801) are just some of the suggested pro-drugs currently under consideration; Wuhan and our company have suggested others - blocks or impairs viral entry via this method. Studies since fall 2020 have also shown that RX concentrated Vitamin D itself, in various forms, also inhibits both ACE2, and its precurssor, Adam17.

The use of bisphonate diuretics or high blood pressure medications, used by some 100 million Americans, also potentially impacts this process, depending on the dosage of the ACE inhibitor used: studies have shown that ACE inhibitors of less than 25 mg per day inhibit Covid19, whilst doses of 25 mg or higher exaggerate it.

03

Viral Activation and Translation (Budding)

We think one of the best Covid-19 activation-inhibiting antivirals is the pro-drug, Nafamostat, funded by Japan and Korea. Nafamostat has always shown very high efficacy - up to 85% against the TMPRSS-2 receptor that allows the virus to activate, after attaching to the ACE2 receptors. But in its earliest forms, Nafamostat was only available as an IV - like the potent steroid that our company supported first patended use for Covid19 for, Dexamathesone.

But whereas Dexamathesone, made by Pfizer, never progressed past the IV form - thus limiting its use as a widespread early treatment - Japan and Korea funded a special pilot study to make this drug easily dosed and transported, and it now is available outside of the US, in nasal spray form. A truly miraculous drug!

Other options to Nafamostat, inside the US, include concentrated Vitamin D, in its seco-steroid form: available for IV, shot, or oral dosage. Like Nafamostat, this form of RX D was used first against tumors and prostate cancer - showing us that the same function is already performed naturally by our human systems, when we support our Innate Immunity, and do not allow it to become Vitamin D, or other nutrient- depleted, or overloaded by stress.

How our little miracles, our children, clued us in to early treatment & cure options. We think the world was just not ready to hear them, preferring the pyschological familiarity of a vaccine.

The risk of a child becoming seriously ill or dying from Covid19 is 'somewhere between 0% and an infinitesimal percent."

- Johns Hopkins University, Fall 2021

We observed striking differences between the pediatric and adult study participants regarding the composition of the immune cell and epithelial cell compartment in the nasal mucosa. While immune cells were rarely detected in nasal samples from healthy adults, samples from SARS-CoV-2-negative children contained high amounts of almost each immune cell subset with an overall dominance of neutrophils. (See cite)

PEDIATRIC INNATE IMMUNITY V. PFIZER ADAPTIVE IMMUNITY

Instantaneous Viral Recognition (Throat & Nasal Membranes)
Not Covid- or Strain-Specific ("Oh gosh, a virus!")
Early attack initiation keeps microbial load to a minimum, so child can clear it from the body in 1 to 2 days, asymptomatic. All this is happening well before the Adaptive, Antibody stage.

Late-Stage Viral Recognition - After Lung Infection
Limited specificity to some Covid strains only
Because the vaccines wait until the virus has started replicating to initiate antibody (antigen) response, microbial load has already built up to overwhelming levels, causing severe symptoms or death in vulnerable adults.

Why Child Immunity Understanding is Critical to Pandemic Therapeutic Design, and Understanding Vaccine Failure

The world needs to understand Children's Innate Immune response to Covid because it WORKS. The vaccines offer only a fleeting, dependency-cycle, unreliable back-end immunity. And they may in fact, be further harmful in that they may actually be triggering the rapid viral mutations into new variants and strains. (Common in nature, when a virus or bacteria is threatened in its host or its environment.)

Just as we would study and reverse engineer any enemy weapon, jet, or missile; to see if it offered better or worse capabilities than our own military, we and other researchers worldwide have set about understanding and copying components of a child's Innate Immunity. This is after all where the earliest antibiotic and antiviral drug design originated, with medical researchers copying Innate Immunity. They just were not sophisticate enough to differentiate between child and adult and elderly Innate Immunity. For Covid19, these are critical, life-impacting distinctions.